rs1333047

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (15)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atherosclerosis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.15
p 6.0e-47
N 600,264
Major Consortium StudyLarge GWAS
multi-ancestry

aneurysm

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.13
p 3.0e-46
N 439,723
Major Consortium StudyLarge GWAS
European

intermediate coronary syndrome

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.17
p 5.0e-46
N 610,631
Major Consortium StudyLarge GWAS
multi-ancestry

aortic aneurysm

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.13
p 5.0e-40
N 441,700
Major Consortium StudyLarge GWAS
European

hemorrhoid

Zheng T et al. “Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.” Gut 70(8):1538-49 (2021)
Allele A
OR 1.04
p 8.0e-28
N 944,133
Large GWAS
European

cerebrovascular disorder

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.07
p 1.0e-26
N 597,128
Major Consortium StudyLarge GWAS
multi-ancestry

congestive heart failure

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.10
p 5.0e-19
N 400,487
Major Consortium StudyLarge GWAS
multi-ancestry

stroke

Zhou W et al. “Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.” Cell Genomics 2(10):100192 (2022)
Allele T
OR 0.06
p 7.0e-19
N 1,370,901
Meta-analysisLarge GWAS
multi-ancestry

Vasodilators used in cardiac diseases use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele T
OR 0.17
p 5.0e-18
N 242,659
Major Consortium StudyLarge GWAS
European

erythrocyte count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.02
p 2.0e-14
N 405,366
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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