rs13331259
This is a intron variant variant in the FAM234A gene.
▶GWAS Catalog Trait Associations (11)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (11)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
mean corpuscular hemoglobin concentration
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele A
OR 0.66
p 2.0e-239
N 11,974
Large GWAS
African American or Afro-Caribbean, African unspecified
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele A
OR 0.40
p 6.0e-96
N 52,648
Large GWAS
multi-ancestry
mean corpuscular hemoglobin
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele G
OR 1.60
p 4.0e-227
N 46,241
Large GWAS
multi-ancestry
Gurdasani D et al. “Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.” Cell 179(4):984-1002.e36 (2019)
Allele G
OR 0.70
p 9.0e-44
N 7,526
Large GWAS
Sub-Saharan African
erythrocyte volume
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele G
OR 3.72
p 6.0e-205
N 48,830
Large GWAS
multi-ancestry
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele G
OR 0.71
p 8.0e-22
N 9,298
Large GWAS
Hispanic or Latin American
Gurdasani D et al. “Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.” Cell 179(4):984-1002.e36 (2019)
Allele G
OR 0.65
p 3.0e-38
N 7,526
Large GWAS
Sub-Saharan African
erythrocyte count
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele G
OR 0.18
p 3.0e-77
N 44,470
Large GWAS
multi-ancestry
anemia (phenotype)
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.19
p 1.0e-32
N 109,306
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
familial hemolytic anemia
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.48
p 5.0e-33
N 120,142
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
hemoglobin measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.15
p 3.0e-114
N 584,680
Major Consortium StudyLarge GWAS
multi-ancestry
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele A
OR 0.27
p 1.0e-31
N 62,461
Large GWAS
multi-ancestry
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele A
OR 0.25
p 3.0e-41
N 15,133
Large GWAS
African American or Afro-Caribbean, African unspecified
inherited hemoglobinopathy
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.94
p 4.0e-53
N 121,192
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
Iron deficiency anemia
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.27
p 2.0e-38
N 114,708
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
red blood cell density
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele A
OR 0.40
p 3.0e-96
N 14,222
Large GWAS
African American or Afro-Caribbean, African unspecified
About FAM234A
Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]
View all FAM234A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…