rs1345203

This variant is located in the MIR4435-2HG gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele T
OR 0.02
p 3.0e-15
N 697,734
Meta-analysisLarge GWAS
European

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)
Allele T
OR —
p 1.0e-12
N 2,535,601
Large GWAS
multi-ancestry
Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)
Allele T
OR 0.03
p 3.0e-8
N 6,710,881
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Exhaustive Search of the SNP-SNP Interactome Identifies Epistatic Effects on Brain Volume in Two Cohorts
AssociationN=1,490Derrek P. Hibar et al.(2013)· Lecture Notes in Computer Science

This study conducted an exhaustive genome-wide SNP-SNP interaction analysis in the ADNI dataset using the EPISIS machine learning algorithm to identify epistatic effects on brain volume. The authors identified a significant SNP pair interaction between rs1345203 and rs1213205 that was associated with ~5% greater temporal lobe volume in both ADNI (n=737) and independent QTIM (n=753) samples, with protective effects observed bilaterally in temporal and occipital brain regions.

Traits studied:Brain structureBrain volumeTemporal lobe volume
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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