rs1366594

This variant is located in the MEF2C-AS1 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

femoral neck bone mineral density

Estrada K et al. “Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.” Nature Genetics 44(5):491-501 (2012)
Allele A
OR —
β 0.080
p 4.0e-61
N 32,961
Meta-analysisLarge GWAS
multi-ancestry

balding measurement

Yap CX et al. “Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.” Nature Communications 9(1):5407 (2018)
Allele C
OR 0.03
p 6.0e-18
N 205,327
Large GWAS
European

bone tissue density

Medina-Gomez C et al. “Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.” American Journal of Human Genetics 102(1):88-102 (2018)
Allele A
OR —
β 0.051
p 5.0e-16
N 66,945
Meta-analysisLarge GWAS
multi-ancestry
Rivadeneira F et al. “Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.” Nature Genetics 41(11):1199-206 (2009)
Allele A
OR 0.09
p 1.0e-13
N 19,195
Meta-analysisLarge GWAS
European
Duncan EL et al. “Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.” Plos Genetics 7(4):e1001372 (2011)
Allele A
OR 0.14
p 8.0e-10
N 1,955
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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