rs1381928

This variant is located in the RERE gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma, body mass index

Zhu Z et al. “Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank.” The Journal of Allergy and Clinical Immunology 145(2):537-549 (2020)
Allele G
OR —
p 4.0e-10
N 457,822
Major Consortium StudyLarge GWAS
European

asthma

Jia G et al. “Discerning asthma endotypes through comorbidity mapping.” Nature Communications 13(1):6712 (2022)
Allele G
OR 0.96
p 4.0e-9
N 305,098
Large GWAS
multi-ancestry

About RERE

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

View all RERE variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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