rs138641402
This is a intergenic variant variant in the LOC105377462 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
FEV/FVC ratio
Wain LV et al. “Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.” Nature Genetics 49(3):416-425 (2017)
Allele T
OR 0.08
p 5.0e-33
N 48,943
Large GWAS
European
FEV/FVC ratio, response to bronchodilator
Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)
Allele A
OR —
β 0.019
p 2.0e-18
N 13,532
Large GWAS
multi-ancestry
forced expiratory volume, response to bronchodilator
Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)
Allele A
OR —
β 0.083
p 9.0e-15
N 13,532
Large GWAS
multi-ancestry
forced expiratory volume
Wain LV et al. “Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.” Nature Genetics 49(3):416-425 (2017)
Allele T
OR 0.05
p 2.0e-11
N 48,943
Large GWAS
European
emphysema pattern measurement
Castaldi PJ et al. “Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.” American Journal of Respiratory and Critical Care Medicine 190(4):399-409 (2014)
Allele A
OR 0.03
p 2.0e-9
N 9,614
Large GWAS
multi-ancestry
chronic obstructive pulmonary disease
Lee JH et al. “Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.” Respiratory Research 15(1):113 (2014)
Allele A
OR 1.30
p 4.0e-9
N 7,297
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…