rs1386494

This is a comprehensive review of post-mortem brain tissue studies examining the neurobiology of suicidal behavior. The paper synthesizes findings on genetic studies, proteomics, neurotransmitter systems (serotonergic, noradrenergic, dopaminergic, glutamatergic), cell signaling, neural plasticity, and neuroendocrinology associated with suicide. Key genetic variants discussed include COMT val158met, TPH2 rs1386494, ADRA2B rs1018351, SLC6A3 rs403636, SAT1 rs6526342, HTR2C Cys23Ser, BDNF Val66Met, and 5-HTTLPR polymorphism.

This case-control association study examined 719 war-trauma survivors from the Balkans to investigate the role of serotonergic gene polymorphisms in PTSD development. A nominal significant association was found between the HTR1A SNP rs6295 and Brief Symptom Inventory scores in lifetime PTSD patients (P=0.018 dominant model), with the minor C allele conveying increased risk. However, no significant associations were found for TPH2 SNPs rs11178997 and rs1386494, and the HTR1A findings did not survive Bonferroni correction.