rs138715366
This is a intron variant variant in the YKT6 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
birth weight
Warrington NM et al. “Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.” Nature Genetics 51(5):804-814 (2019)
Allele C
OR 0.24
p 4.0e-61
N 321,223
Large GWAS
multi-ancestry
Horikoshi M et al. “Genome-wide associations for birth weight and correlations with adult disease.” Nature 538(7624):248-252 (2016)
Allele C
OR 0.24
p 1.0e-26
N 142,558
Large GWAS
multi-ancestry
birth weight, parental genotype effect measurement
Warrington NM et al. “Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.” Nature Genetics 51(5):804-814 (2019)
Allele C
OR 0.12
p 2.0e-13
N 230,069
Large GWAS
European
fetal genotype effect measurement, placenta mass
Beaumont RN et al. “Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.” Nature Genetics 55(11):1807-1819 (2023)
Allele C
OR 0.20
p 8.0e-9
N 65,405
Large GWAS
European
About YKT6
This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]
View all YKT6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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