rs140564406
This variant is located in the AOPEP gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heart failure
Henry A et al. “Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.” Nature Genetics 57(4):815-828 (2025)
Allele A
OR 0.03
p 1.0e-9
N 1,968,806
Meta-analysisLarge GWAS
multi-ancestry
About AOPEP
This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
View all AOPEP variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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