rs140570886

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GWAS Catalog Trait Associations (71)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cholesteryl esters to total lipids in large VLDL percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele C
OR 0.40
p 8.0e-262
N 241,027
Large GWAS
European

lipoprotein A measurement, apolipoprotein A 1 measurement

Mack S et al. “A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.” Journal of Lipid Research 58(9):1834-1844 (2017)
Allele C
OR 43.43
p 2.0e-210
N 13,781
Meta-analysisLarge GWAS
European

coronary artery disease

van der Harst P et al. “Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.” Circulation Research 122(3):433-443 (2018)
Allele T
OR 0.48
p 3.0e-87
N 296,525
Large GWAS
Klarin D et al. “Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.” Nature Genetics 49(9):1392-1397 (2017)
Allele T
OR 1.92
p 2.0e-21
N 120,286
Major Consortium StudyLarge GWAS
multi-ancestry

linoleic acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele C
OR —
p 6.0e-86
N 239,268
Large GWAS
European
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.24
p 2.0e-47
N 115,006
Large GWAS
European

triglycerides to total lipids in large VLDL percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele C
OR 0.23
p 1.0e-85
N 241,027
Large GWAS
European

omega-6 polyunsaturated fatty acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele C
OR —
p 6.0e-72
N 239,268
Large GWAS
European
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.22
p 8.0e-42
N 115,006
Large GWAS
European

triglyceride measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.10
p 9.0e-47
N 394,642
Large GWAS
European
Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)
Allele C
OR 0.08
p 1.0e-16
N 361,194
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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