rs140871186
This is a regulatory region variant variant in the GTF3C5 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Sepsis, mortality
Butler-Laporte G et al. “Elevated body mass index is associated with an increased risk of infectious disease admissions and mortality: a mendelian randomization study.” Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases (2020)
Allele C
OR 0.33
p 3.0e-8
N 2,037
Large GWAS
European
About GTF3C5
Enables RNA polymerase III general transcription initiation factor activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within skeletal muscle cell differentiation. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Jul 2025]
View all GTF3C5 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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