rs1417182
This is a intron variant variant in the GRIK2 gene.
▶Research that mentions this SNP (1)
▶Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive–compulsive symptomsAssociationN=250Jun Cai et al.(2013)· Psychopharmacology
This study examined whether polymorphisms in glutamate-related genes SLC1A1, GRIN2B, and GRIK2 are associated with clozapine-induced obsessive-compulsive symptoms in 250 Han Chinese schizophrenia patients. Rs890 (GRIN2B) showed significant association with OC symptoms (OR=1.75, p=0.002), while rs2228622 (SLC1A1) showed trends (OR=1.68, p=0.017). A significant gene-gene interaction between rs2228622 and rs890 was identified (p=0.0021), with AA/TT genotypes showing elevated symptom severity.
About GRIK2
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008]
View all GRIK2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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