rs141870005
This variant is located in the TRPM2 gene.
▶ClinVar annotation
Likely Benign★★★☆
2 submitters2 publicationsAbout TRPM2
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
View all TRPM2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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