rs141962517

This is a intron variant variant in the CADPS gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure, self reported educational attainment

de las Fuentes L et al. “Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.” Molecular Psychiatry 26(6):2111-2125 (2021)

Allele T

OR 12.85

p 3.0e-10

N 101,598

Meta-analysisLarge GWAS

multi-ancestry

About CADPS

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

View all CADPS variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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