rs142101835
This variant is located in the IRS1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body fat percentage
Nagy R et al. “Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.” Genome Medicine 9(1):23 (2017)
Allele G
OR 5.54
p 3.0e-8
N 26,343
Major Consortium StudyLarge GWAS
European
▶ClinVar annotation
Likely Benign★★★☆
2 submitters1 publicationAbout IRS1
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
View all IRS1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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