rs1423096

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

resistin measurement

Kawamura R et al. “Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.” Physiological Genomics 48(11):874-881 (2016)
Allele T
OR 4.79
p 2.0e-209
N 448
Small GWAS
East Asian
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele T
OR 0.34
p 7.0e-12
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
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Research that mentions this SNP (1)

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Common quantitative trait locus downstream of RETN gene identified by genome‐wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect
AssociationN=4,341Chia‐Min Chung et al.(2014)· Diabetes/Metabolism Research and Reviews

This genome-wide association study identified two SNPs (rs3745367 and rs1423096) in the RETN gene associated with circulating resistin levels in Han Chinese hypertensive subjects. Using Mendelian randomization in an independent cohort (CVDFACTS), rs1423096 was significantly associated with metabolic syndrome risk (OR=2.21, p=0.0034) and type 2 diabetes mellitus (OR=1.62, p=0.0063), providing evidence that resistin causally contributes to T2DM development.

Traits studied:HDL-C levelsHypertensionInsulin resistanceMetabolic syndromeResistin levelsType 2 diabetes mellitus
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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