rs1424110

This is a intron variant variant in the WWOX gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

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Research that mentions this SNP (1)

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Genome‐wide linkage scan for prostate cancer susceptibility from the university of michigan prostate cancer genetics project: Suggestive evidence for linkage at 16q23
AssociationN=471Ethan M. Lange et al.(2009)· The Prostate

Genome-wide linkage scan on 131 Caucasian prostate cancer families from the University of Michigan PCGP identified suggestive evidence for prostate cancer linkage at 16q23 (LOD = 2.70 near rs1079635), confirming findings from prior studies in the same region. The linkage peak includes candidate genes WWOX and ATBF1, both known tumor suppressors. In a subset of 57 families with aggressive prostate cancer, additional suggestive linkage was detected at 9q33 (LOD = 2.96 near rs1405), though this region lacks prior replication.

Traits studied:Aggressive prostate cancerProstate cancer
PubMedDOIMetascience Observatory

About WWOX

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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