rs142630154
This is a downstream gene variant variant in the IRGQ gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
level of phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.45
p 6.0e-31
N 47,745
Large GWAS
European
About IRGQ
Enables protein-macromolecule adaptor activity. Involved in positive regulation of autophagy; protein quality control for misfolded or incompletely synthesized proteins; and substrate localization to autophagosome. Is active in autophagosome and lysosome. [provided by Alliance of Genome Resources, Jul 2025]
View all IRGQ variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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