rs14314
This variant is located in the LRP11 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
brain attribute
van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)
Allele C
OR 8.35
p 7.0e-17
N 33,748
Large GWAS
European
S-adenosylhomocysteine measurement
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele C
OR 0.08
p 4.0e-16
N 3,629
Large GWAS
European
hippocampal volume
Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele C
OR 0.06
p 7.0e-15
N 38,977
Large GWAS
European, East Asian
subiculum volume
Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele C
OR 0.06
p 1.0e-14
N 38,977
Large GWAS
European, East Asian
amygdala volume
Ji Y et al. “Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.” Nature Genetics 57(4):839-850 (2025)
Allele C
OR 0.04
p 3.0e-9
N 42,397
Large GWAS
multi-ancestry
About LRP11
Enables phosphoprotein binding activity. Predicted to be involved in several processes, including response to cold; response to heat; and response to water deprivation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all LRP11 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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