rs143642746

This is a regulatory region variant variant in the MMP24-AS1-EDEM2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

vitamin K-dependent protein C measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.20

p 2.0e-20

N 47,745

Large GWAS

European

migraine disorder, blood insulin amount

Islam MR et al. “Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.” Human Genetics 142(8):1149-1172 (2023)

Allele A

OR 1.14

p 1.0e-8

N 1,025,244

Large GWAS

European

About MMP24-AS1-EDEM2

This record represents naturally-occurring readthrough transcription between upstream GeneID:101410538 (MMP24 antisense RNA 1) and the ER degradation enhancing alpha-mannosidase like protein 2 (EDEM2) gene. Readthrough transcripts may encode proteins similar to those encoded by the EDEM2 gene. [provided by RefSeq, Aug 2017]

View all MMP24-AS1-EDEM2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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