rs144363592

This is a protein-altering variant in the SIGLEC7 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

amount of sialic acid-binding Ig-like lectin 7 (human) in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.94

p 1.0e-34

N 47,745

Large GWAS

European

sialic acid-binding Ig-like lectin 7 amount

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele A

OR 0.97

p 2.0e-18

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About SIGLEC7

Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all SIGLEC7 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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