rs1445898

This is a protein-altering variant in the CAPSL gene.

▶

Research that mentions this SNP (1)

▶
Study of the association between the CAPSL-IL7R locus and type 1 diabetes
AssociationN=2,106Santiago JL et al.(2008)· Diabetologia

This case-control association study replicates the CAPSL-IL7R locus association with type 1 diabetes in Spanish (301 cases, 646 controls) and Dutch (429 cases, 720 controls) cohorts. The CAPSL rs1445898 TT genotype confers protection (pooled Mantel-Haenszel OR 0.71, p=0.005), with stronger protective effect in early-onset patients (OR 0.26, p=0.001). IL7R rs6897932 TT genotype also shows protection in early-onset cases (OR 0.18, p=0.02).

Traits studied:Type 1 diabetes
PubMedDOIMetascience Observatory

About CAPSL

Predicted to enable calcium ion binding activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all CAPSL variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…