rs1449263
This is a upstream gene variant variant.
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neutrophil count
Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)
Allele C
OR —
p 3.0e-25
N 234,802
Large GWAS
European
lymphocyte count
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 3.0e-23
N 417,277
Major Consortium StudyLarge GWAS
multi-ancestry
monocyte percentage of leukocytes
Choe EK et al. “Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits.” Scientific Reports 12(1):1930 (2022)
Allele T
OR 0.16
p 6.0e-18
N 9,689
Large GWAS
East Asian
basophil count
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele T
OR 0.02
p 5.0e-14
N 474,001
Large GWAS
European
eosinophil count
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.01
p 5.0e-13
N 394,642
Large GWAS
European
reticulocyte amount
Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele T
OR 0.01
p 3.0e-10
N 408,112
Large GWAS
European
monocyte count
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele C
OR 0.10
p 6.0e-87
N 88,929
Large GWAS
East Asian
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.12
p 1.0e-116
N 73,142
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
Keller MF et al. “Trans-ethnic meta-analysis of white blood cell phenotypes.” Human Molecular Genetics 23(25):6944-60 (2014)
Allele C
OR 0.04
p 7.0e-14
N 33,729
Meta-analysisLarge GWAS
multi-ancestry
Nalls MA et al. “Multiple loci are associated with white blood cell phenotypes.” Plos Genetics 7(6):e1002113 (2011)
Allele C
OR 0.04
p 3.0e-23
N 19,509
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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