rs1451534927
This variant is located in the NFKBIE gene.
▶ClinVar annotation
About NFKBIE
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
View all NFKBIE variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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