rs145813322

This variant is located in the CRKL gene.

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ClinVar annotation

Benign★★★☆
4 submitters2 publications

not provided; CRKL-related disorder; Sarcoma; Melanoma

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About CRKL

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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