rs146337789

This is a protein-altering variant in the AOPEP gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Hodgkins lymphoma

Osman Y et al. “Functional multigenic variations associated with hodgkin lymphoma.” International Journal of Laboratory Hematology 43(6):1472-1482 (2021)

Allele T

OR —

β 0.035

p 3.0e-11

N 97

Small GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About AOPEP

This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

View all AOPEP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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