rs146460124

This is a protein-altering variant in the KLRF1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

killer cell lectin-like receptor subfamily F member 1 level

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 2.21

p 1.0e-273

N 47,745

Large GWAS

European

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele A

OR 0.82

p 2.0e-22

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About KLRF1

KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]

View all KLRF1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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