rs1465107
This is a intron variant variant in the MAOA gene.
▶Research that mentions this SNP (1)
▶Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese populationAssociationN=1,122Yuhui Sun et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A case-control study in a Chinese Han population examined the role of the MAOA gene in paranoid schizophrenia by genotyping 1 VNTR polymorphism and 41 SNPs in 555 patients and 567 controls. While individual SNP alleles showed marginal associations (e.g., rs6323-G: OR=0.81, p=0.03; rs1137070-C: OR=0.77, p=0.01), these did not survive multiple testing correction. Haplotypic analysis revealed significant associations in females, particularly for VNTR(L)-rs6323(T) (p=0.03, OR=1.78) and VNTR(L)-rs1137070(C) (p=0.02, OR=2.71) haplotypes showing increased schizophrenia risk. Gene expression analysis of MAOA mRNA in 73 drug-free patients found no significant differences by genotype, suggesting haplotypic interactions may contribute to disease susceptibility through mechanisms other than altered mRNA expression.
About MAOA
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
View all MAOA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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