rs1465146591
This variant is located in the ZRANB3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
type 2 diabetes mellitus
Adeyemo AA et al. “ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.” Nature Communications 10(1):3195 (2019)
Allele A
OR 0.65
p 7.0e-9
N 5,231
Large GWAS
Sub-Saharan African
About ZRANB3
Enables ATP-dependent DNA/DNA annealing activity; DNA endonuclease activity; and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in DNA repair; replication fork reversal; and response to UV. Located in nuclear replication fork and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all ZRANB3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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