rs146632589

This is a intron variant variant in the ELOVL2 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6) measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele T
OR 0.12
p 2.0e-21
N 14,296
Large GWAS
European

1-docosahexaenoyl-GPC (22:6) measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele T
OR 0.10
p 8.0e-18
N 14,296
Large GWAS
European

1-docosahexaenoyl-GPE (22:6) measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele T
OR 0.09
p 1.0e-14
N 14,296
Large GWAS
European

docosahexaenoate DHA; 22:6n3 measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele T
OR 0.08
p 8.0e-12
N 14,296
Large GWAS
European

About ELOVL2

Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

View all ELOVL2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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