rs147106204

This is a intron variant variant in the WWC1 gene.

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Research that mentions this SNP (1)

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Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry
AssociationN=3,686Shengfeng Wang et al.(2018)· Molecular Carcinogenesis

This case-control study of 3,686 women of African ancestry (1,657 cases, 2,029 controls) examined 7,086 SNPs across 35 Hippo pathway genes to identify associations with breast cancer risk. The combined effect of genetic variations in the Hippo pathway was significantly associated with estrogen receptor-positive (ER+) breast cancer (pathway-level P = 0.019), with WWC1 as the leading gene. The most significant individual SNP was rs147106204 in WWC1 (OR = 0.53, 95% CI = 0.41-0.70, P adj = 0.025), with five linked SNPs also showing significant associations with ER+ breast cancer risk.

Traits studied:Breast cancerEstrogen receptor-negative breast cancerEstrogen receptor-positive breast cancer
PubMedDOIMetascience Observatory

About WWC1

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

View all WWC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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