rs1477196

This is a intron variant variant in the FTO gene.

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Research that mentions this SNP (1)

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Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity
AssociationN=704Evadnie Rampersaud et al.(2008)· Archives of Internal Medicine

This study examined 704 Old Order Amish individuals and identified 26 FTO gene variants associated with BMI (P=.04 to <.001), with rs1861868 (0.75 BMI increase per A allele, P<.001) and rs1477196 (0.84 BMI increase per C allele, P<.001) showing the strongest associations. Notably, the study found a significant gene-by-environment interaction where increased physical activity substantially blunted the effects of FTO variants on body weight, suggesting that genetic predisposition to obesity can be mitigated through adequate physical activity.

Traits studied:Body mass indexBody weightFat massObesityOverweightPercentage of body fatWaist circumference
PubMedDOIMetascience Observatory

About FTO

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

View all FTO variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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