rs148348463
This variant is located in the CEP43 gene.
▶ClinVar annotation
not specified; Ovarian serous cystadenocarcinoma; Malignant tumor of esophagus; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Colon adenocarcinoma; Thyroid cancer, nonmedullary, 1; Familial cancer of breast
View on ClinVar →About CEP43
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
View all CEP43 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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