rs1490265

This variant is located in the SUCLG2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

vital capacity

Wain LV et al. “Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.” Nature Genetics 49(3):416-425 (2017)

Allele A

OR 0.03

p 2.0e-9

N 48,943

Large GWAS

European

He Y et al. “Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction.” Nature Genetics 58(2):289-298 (2026)

Allele A

OR 0.01

p 2.0e-8

N 129,680

Large GWAS

East Asian

About SUCLG2

This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

View all SUCLG2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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