rs149033733

This is a regulatory region variant variant in the LAPTM4A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

matrilin-3 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.46

p 3.0e-16

N 47,745

Large GWAS

European

About LAPTM4A

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

View all LAPTM4A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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