rs149282327

This is a intron variant variant in the LRRC7 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

breast benign neoplasm

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 2.80
p 3.0e-12
N 571,990
Major Consortium StudyLarge GWAS
multi-ancestry

About LRRC7

Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of neuron projection development; and protein localization to membrane. Located in several cellular components, including centrosome; cytosol; and nucleoplasm. Implicated in cocaine dependence. [provided by Alliance of Genome Resources, Jul 2025]

View all LRRC7 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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