rs149288352

This is a intron variant variant in the FAF1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart failure

Henry A et al. “Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.” Nature Genetics 57(4):815-828 (2025)
Allele A
OR 0.10
p 3.0e-9
N 1,968,806
Meta-analysisLarge GWAS
multi-ancestry

QRS duration

van Setten J et al. “Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.” European Journal of Human Genetics : Ejhg 27(6):952-962 (2019)
Allele A
OR 1.51
p 4.0e-8
N 25,509
Meta-analysisLarge GWAS
multi-ancestry

About FAF1

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]

View all FAF1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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