rs149615348

This is a variant in the CRISPLD2 gene that changes a methionine to an isoleucine.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cysteine-rich secretory protein LCCL domain-containing 2 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele A

OR —

β 1.350

p 3.0e-17

N 3,301

Large GWAS

European

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ClinVar annotation

Likely Benign★☆☆☆

2 submitters

CRISPLD2-related disorder

View on ClinVar →

About CRISPLD2

Predicted to enable glycosaminoglycan binding activity. Involved in face morphogenesis. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]

View all CRISPLD2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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