rs149671592

This is a regulatory region variant variant in the IGLON5 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood protein amount

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.36

p 2.0e-25

N 47,745

Large GWAS

European

CD33 molecule amount

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele T

OR 1.14

p 9.0e-16

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About IGLON5

Predicted to act upstream of or within motor behavior and neuromuscular process controlling balance. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

View all IGLON5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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