rs149934734

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chromosome, telomeric region length

Burren OS et al. “Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.” Nature Genetics 56(9):1832-1840 (2024)
Allele C
OR 0.12
p 3.0e-77
N 438,351
Major Consortium StudyLarge GWAS
European
Liu WS et al. “Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications.” Geroscience 46(5):5365-5385 (2024)
Allele C
OR 0.09
p 1.0e-34
N 327,790
Large GWAS
European

uterine fibroid

Kim J et al. “Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.” Nature Communications 16(1):2273 (2025)
Allele T
OR 0.29
p 8.0e-28
N 434,152
Meta-analysisLarge GWAS
European
Rafnar T et al. “Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.” Nature Communications 9(1):3636 (2018)
Allele T
OR 1.29
p 3.0e-12
N 539,925
Large GWAS
European
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.35
p 5.0e-17
N 338,926
Large GWAS
multi-ancestry
Gallagher CS et al. “Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.” Nature Communications 10(1):4857 (2019)
Allele T
OR 1.33
p 1.0e-27
N 244,324
Large GWAS
European

Uterine leiomyoma

Sliz E et al. “Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata.” Nature Communications 14(1):542 (2023)
Allele T
OR 1.38
p 2.0e-27
N 367,903
Large GWAS
European

thyroid carcinoma

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele T
OR 0.27
p 3.0e-13
N 2,917,628
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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