rs150611042
This variant is located in the ORM1 gene.
▶GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
glycoprotein measurement
Yuan F et al. “Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses.” British Journal of Cancer 133(1):94-103 (2025)
Allele A
OR 0.12
p 7.0e-77
N 199,732
Large GWAS
European
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.07
p 2.0e-15
N 128,809
Large GWAS
multi-ancestry
coagulation factor XA measurement
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele A
OR 0.61
p 4.0e-48
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
coagulation factor X amount
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele A
OR 0.58
p 5.0e-44
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
vitamin k-dependent protein S measurement
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele A
OR 0.53
p 6.0e-37
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
tissue factor pathway inhibitor amount
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele A
OR 0.35
p 4.0e-17
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
protein measurement
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.21
p 2.0e-15
N 10,708
Large GWAS
European
thrombin generation potential measurement
Rocanin-Arjo A et al. “A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.” Blood 123(5):777-85 (2014)
Allele A
OR 0.35
p 7.0e-15
N 1,967
Meta-analysis
European
blood protein amount
Suhre K et al. “A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform.” Nature Genetics 57(12):2987-2996 (2025)
Allele A
OR 0.52
p 3.0e-12
N 1,256
Large GWAS
multi-ancestry
triglyceride measurement
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele A
OR 0.02
p 2.0e-8
N 1,320,016
Large GWAS
European
fatty acid amount
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele A
OR —
p 5.0e-8
N 239,268
Large GWAS
European
About ORM1
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
View all ORM1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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