rs151269874
This is a upstream gene variant variant in the TMEM231 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
response to darapladib, Diarrhea
Yeo A et al. “Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.” Plos One 12(7):e0182115 (2017)
Allele T
OR 4.18
p 2.0e-9
N 481
Meta-analysisSmall GWAS
European
About TMEM231
This gene encodes a transmembrane protein, which is a component of the B9 complex involved in the formation of the diffusion barrier between the cilia and plasma membrane. Mutations in this gene cause Joubert syndrome (JBTS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
View all TMEM231 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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