rs1517618

This is a synonymous variant in the SLCO3A1 gene — it does not change the protein's amino acid sequence.

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Research that mentions this SNP (1)

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ABCB1andABCC1variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients
AssociationN=187Antonio V.C. Coelho et al.(2013)· The Journal of Clinical Pharmacology

This retrospective cohort study of 187 Brazilian HIV patients examined associations between seven SNPs in five pharmacokinetic genes and virological failure on first-line protease inhibitor-based antiretroviral therapy. Two variants were significantly associated with treatment failure: rs1045642 (ABCB1) and rs212091 (ABCC1), suggesting that genetic variation in drug transporter proteins influences treatment outcomes in this population.

Traits studied:HIV virological failure on protease inhibitor antiretroviral therapyResponse to first-line highly active antiretroviral therapy (HAART)
PubMedDOIMetascience Observatory

About SLCO3A1

Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Involved in positive regulation of MAPK cascade; positive regulation of canonical NF-kappaB signal transduction; and prostaglandin transport. Located in basal plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all SLCO3A1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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