rs1537372

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

peripheral vascular disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.11
p 1.0e-45
N 599,134
Major Consortium StudyLarge GWAS
multi-ancestry

peripheral arterial disease

van Zuydam NR et al. “Genome-Wide Association Study of Peripheral Artery Disease.” Circulation. Genomic and Precision Medicine 14(5):e002862 (2021)
Allele T
OR 1.12
p 7.0e-41
N 461,634
Large GWAS
multi-ancestry
Klarin D et al. “Genome-wide association study of peripheral artery disease in the Million Veteran Program.” Nature Medicine 25(8):1274-1279 (2019)
Allele T
OR 1.12
p 4.0e-39
N 243,060
Major Consortium StudyLarge GWAS
multi-ancestry

Barrett's esophagus

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.13
p 3.0e-26
N 446,841
Major Consortium StudyLarge GWAS
European

colorectal cancer, colorectal adenoma

Huyghe JR et al. “Discovery of common and rare genetic risk variants for colorectal cancer.” Nature Genetics 51(1):76-87 (2019)
Allele G
OR 1.05
p 1.0e-8
N 125,478
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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ATG12 expression quantitative trait loci associated with head and neck squamous cell carcinoma risk in a Chinese Han population
AssociationN=1,056Xueyao Song et al.(2018)· Molecular Carcinogenesis

This study investigated the association of MGMT enhancer variant rs11016629 with glioma susceptibility and progression in 402 patients and 654 controls. The TG genotype was associated with increased glioma risk (OR=1.41, 95% CI 1.03-1.93, P=0.034), particularly in WHO grade IV tumors (OR=1.59, P=0.023). In patients who underwent gross total resection, carriers with TG/TT genotypes had worse progression-free survival (HR=2.66, 95% CI 1.23-5.79, P=0.014) compared to GG carriers.

Traits studied:GlioblastomaGliomaHigh-grade gliomaWHO grade IV glioma
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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