rs1556640
This variant is located in the PERP gene.
▶Research that mentions this SNP (1)
▶Genome‐wide association study of theta band event‐related oscillations identifies serotonin receptor geneHTR7influencing risk of alcohol dependenceAssociationN=2,159Mark Zlojutro et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This genome-wide association study identified four genes influencing theta band event-related oscillations, a heritable neuroelectrical trait associated with alcohol dependence. The strongest association for alcohol dependence risk was rs7916403 in serotonin receptor gene HTR7 on chromosome 10q23 (combined P = 1.53 × 10⁻⁴), with a recessive effect (OR = 1.32–1.37, P = 0.031–0.042). Other significant markers included rs4907240 in ARID5A (P = 3.68 × 10⁻⁶), rs13831 in GNAS1, and non-synonymous rs2294015 in ANXA13.
About PERP
Involved in positive regulation of neutrophil chemotaxis and positive regulation of proteolysis. Predicted to be located in desmosome and plasma membrane. Predicted to be active in cell-cell junction. Implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. [provided by Alliance of Genome Resources, Jul 2025]
View all PERP variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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