rs1565684
This variant is located in the NAT2 gene.
▶Research that mentions this SNP (1)
▶No association between apolipoprotein E or N‐Acetyltransferase 2 gene polymorphisms and age‐related hearing lossAssociationN=265Piers Dawes et al.(2015)· The Laryngoscope
A candidate gene association study of 265 elderly Caucasian volunteers from the UK found no significant associations between NAT2 or APOE gene polymorphisms and age-related hearing loss (ARHL) using haplotype tagging SNP analysis. Linear regression analysis of 13 NAT2 htSNPs (including rs1799930/NAT2*6A) and APOE ε4 allele presence showed no significant associations (P > 0.05) with three hearing phenotypes (severity, slope, concavity), and epistasis analysis revealed no gene-gene interaction between these loci.
About NAT2
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019]
View all NAT2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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