rs1566045

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

femoral neck bone mineral density

Estrada K et al. “Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.” Nature Genetics 44(5):491-501 (2012)
Allele T
OR —
β 0.060
p 2.0e-22
N 32,961
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
Meta-analysisN=9,658Koller DL et al.(2013)· Journal of Bone and Mineral Research

Meta-analysis of GWAS in 4,061 premenopausal women (ages 20-45) identified two genes associated with bone mineral density at the lumbar spine and femoral neck. WNT16 SNP rs3801387 showed the strongest association (joint p=1.3×10^-11, beta=-0.115) and ESR1/C6orf97 SNPs including rs4870044 (joint p=1.4×10^-10) and rs6930633 (joint p=1.16×10^-8) achieved genome-wide significance. Results were replicated in 5,597 additional premenopausal women from diverse ancestries, confirming that genetic variants in bone formation genes similarly affect peak bone mass during the premenopausal period.

Traits studied:Bone mineral densityFemoral neck BMDLumbar spine BMDOsteoporosisPeak bone mass
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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