rs156697

This is a protein-altering variant in the GSTO2 gene.

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Research that mentions this SNP (1)

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Biological monitoring and the influence of genetic polymorphism of As3MT and GSTs on distribution of urinary arsenic species in occupational exposure workers
AssociationN=201Beata Janasik et al.(2015)· International Archives of Occupational and Environmental Health

This study examined six genetic polymorphisms (As3MT Met287Thr rs11191439, As3MT 5'UTR rs7085104, As3MT rs3740393, As3MT rs3740400, GSTP1 rs1695, GSTO2 rs156697) in 149 copper mill workers and 52 controls. The As3MT rs3740400 GG homozygotes showed significantly higher percentage of inorganic arsenic (iAs) in urine (21.8±2.0% vs 16.0±2.1%, p<0.05) compared to GC+CC genotypes. GSTO2 rs156697 showed strong association with arsenic metabolite patterns. The study concluded that As3MT and GST genotypes may influence arsenic metabolism capacity.

Traits studied:Arsenic metabolismOccupational arsenic exposureUrinary arsenic species distribution
PubMedDOIMetascience Observatory

About GSTO2

The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

View all GSTO2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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