rs1572899
This variant is located in the DISC1 gene.
▶Research that mentions this SNP (1)
▶Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophreniaAssociationN=1,794Kristin K. Nicodemus et al.(2007)· Human Genetics
Case-control and family-based association study in 1,794 individuals (296 cases, 370 controls, and 296 families in NIMH sibling study; 501 cases and 627 controls in German sample) investigating statistical epistasis between COMT polymorphisms (rs2097603, rs4680/Val158Met, rs165599) and SNPs in candidate schizophrenia genes. Found significant gene-gene interactions: three RGS4 SNPs showed increased schizophrenia risk with COMT (LRT P-values 0.02-0.05), six G72/DAOA SNPs exhibited epistasis with COMT, three GRM3 SNPs showed interaction effects, and DISC1 SNPs interacted with COMT Val158Met. Main effects for most candidate genes were null, highlighting the importance of epistatic models in psychiatric genetics.
About DISC1
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
View all DISC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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