rs1572931

This variant is located in the RAB29 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

bilirubin measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.01
p 5.0e-8
N 467,170
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder
ReviewDavid H. Adams et al.(2008)· Human Psychopharmacology: Clinical and Experimental

Literature review of 77 publications examining the effects of genes COMT, MAO-A, MAO-B, DAT, DRD2, VMAT2, TPH2, and SNCA on Parkinson's disease neuropsychiatric symptoms and therapy response. Key polymorphisms include rs1800497 (DRD2) associated with impulse control disorders, rs6269/rs4633/rs4818/rs4680 (COMT) with cognitive decline, and rs1352250/rs6582078 (TPH2) with impulse control. The review identifies genetic predictors for early complications (cognitive decline, depression, psychosis, impulse control disorders) and therapy optimization, relevant for patient selection for deep brain stimulation.

Traits studied:Addiction/substance abuseAnxiety disorderAttention-deficit/hyperactivity disorderBipolar affective disorderCognitive declineDementiaDepressionHallucinationsImpulse control disorderLevodopa dyskinesiaLevodopa responseObsessive-compulsive disorderParkinson's diseasePsychotic disordersSchizophreniaSleep disorders
PubMedDOIMetascience Observatory

About RAB29

Enables several functions, including dynein complex binding activity; guanyl ribonucleotide binding activity; and kinesin binding activity. Involved in several processes, including positive regulation of T cell receptor signaling pathway; positive regulation of receptor recycling; and retrograde transport, endosome to Golgi. Located in several cellular components, including Golgi apparatus; endosome; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all RAB29 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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